Unveiling the Truth: Does Semaglutide Cause Fatigue?

Unveiling the Truth: Does Semaglutide Cause Fatigue? Get the Facts Here!

As the prevalence of type 2 diabetes continues to rise globally, the search for effective treatments remains a top priority in the medical field. One such medication that has gained attention is semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist. However, a common question that arises is, “does semaglutide make you tired?” This article aims to provide a comprehensive answer to this question, backed by scientific research and clinical studies.

Understanding Semaglutide

Semaglutide is a medication used to control blood sugar levels in adults with type 2 diabetes. It works by mimicking the action of a hormone in the body called GLP-1. This hormone helps to regulate blood sugar levels by stimulating the release of insulin when blood sugar levels are high. However, like all medications, semaglutide can have side effects, and fatigue is one that has been reported by some users.

Does Semaglutide Make You Tired?

According to clinical studies, fatigue is a potential side effect of semaglutide. However, it’s important to note that not everyone who takes this medication will experience this side effect. The frequency of fatigue as a side effect is considered to be ‘common’, meaning it may affect up to 1 in 10 people.

In a study published in the Journal of the American Medical Association, 9.3% of participants reported feeling tired after taking semaglutide. However, it’s worth noting that 7.4% of participants who were given a placebo also reported feeling tired. This suggests that while semaglutide may cause fatigue in some people, other factors such as the individual’s overall health, lifestyle, and other medications may also contribute to feelings of tiredness.

Managing Fatigue While Taking Semaglutide

If you’re taking semaglutide and experiencing fatigue, there are several strategies you can employ to manage this side effect:

  • Ensure you’re getting enough sleep. Aim for 7-9 hours per night.

  • Maintain a healthy diet. Eating a balanced diet can help to maintain your energy levels.

  • Stay hydrated. Dehydration can contribute to feelings of fatigue.

  • Exercise regularly. Physical activity can help to boost your energy levels.

If your fatigue persists or worsens, it’s important to speak with your healthcare provider. They may be able to adjust your dosage or suggest alternative treatments.


While semaglutide can cause fatigue in some individuals, it’s important to remember that this side effect is not experienced by everyone. If you’re considering semaglutide as a treatment for type 2 diabetes, discuss the potential side effects with your healthcare provider to make an informed decision. Remember, managing diabetes effectively often involves a combination of medication, lifestyle changes, and regular monitoring of blood sugar levels.

So, does semaglutide make you tired? It can, but with proper management and communication with your healthcare provider, this side effect can be effectively managed.

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